ENSURE phase III trial

The superior efficacy of erlotinib over chemotherapy as first-line treatment for EGFR Mut+ NSCLC, observed in the OPTIMAL study, was confirmed in this broader Asian population. Erlotinib’s favourable safety profile was also confirmed.1

Study design and endpoints1

  • ENSURE was a randomised phase III trial that took place across 30 centres in Malaysia, China and the Philippines.
  • The trial compared erlotinib versus standard chemotherapy as first-line treatment for EGFR Mut+ NSCLC.

ECOG PS (Eastern Co-operative Oncology Group performance status)

Key Results

Efficacy1

Patients who received erlotinib had significantly longer PFS than patients receiving chemotherapy.

Safety1

Patients treated with erlotinib experienced fewer treatment-related severe AEs, fewer Grade ≥3 AEs and fewer dose modifications due to AEs, than patients treated with chemotherapy.

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