JO25567 phase II trial

Combining bevacizumab with erlotinib as first-line treatment for EGFR Mut+ NSCLC resulted in a significant improvement in PFS compared with single-agent erlotinib. This was the first evidence for the efficacy of the combination in this setting. 1

Study design and endpoints1

  • JO25567 was a randomised phase II trial that took place across 30 centres in Japan.
  • The trial compared erlotinib plus bevacizumab versus erlotinib alone as first-line treatment for EGFR Mut+ NSCLC.

ECOG PS (Eastern Co-operative Oncology Group performance status)

Key Results

Efficacy1

Patients who received erlotinib plus bevacizumab had significantly longer PFS than patients receiving single-agent erlotinib.

Safety1

The number of serious AEs and discontinuations were similar between treatment arms, but increased grade ≥3 AEs were observed in the combined treatment group.

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